Cardarine or GW-501516 is a peptide that is classified as a peroxisome proliferator activator receptor agonist or PPAR. Research into the efficacy and potency of the peptide began in the early 2000s and was pioneered by GlaxoSmithKline and Ligand pharmaceutical companies. The main objective of the study was to find a solution for obesity, cardiovascular diseases, and diabetes. Studies showed that Cardarine binds to the PPAR receptor and it accentuates the activity of the co-activator PGC-1α enzyme. This enzyme is essential for the up-regulation of genes, and it is integral in energy expenditure.
Cardarine was administered to research mice, and their metabolic rate monitored. Findings indicated that the mice with the compound had a higher metabolic rate compared to their counterparts. Moreover, further studies have been conducted on the efficacy of the compound in combating type 2 diabetes and obesity. Results showed that it reduced low-density lipoproteins while increasing high-density lipoprotein. Cardarine can activate pathways for exercise that would have otherwise been closed.
Mechanism of action
Cardarine is effective for many things in a biological system. The most important is boosting the test subject’s endurance and keeping it at top performance throughout the exercise regimen. Endurance is an essential feature in workouts because it helps in building more muscles within a short period. Fat loss is another reason why the compound is under research, Cardarine allows the test subject to work out without muscle damage or extra fatigue. The recovery period is also reduced. This means that the test subject can lose weight within a short period while developing huge muscles. It also ensures that you are using nutrients that you are taking in a better way by reducing the amount of fat stored while maximizing the available fat for energy. The mechanism of action is through activation of muscle cells receptors to generate new muscle cells and rejuvenate the existing myoblasts.
Advantages of Cardarine
Cardarine is ideal for neural protection. According to recent research done on guinea pigs, Cardarine can protect brain vessels under stress, and it can prevent the blood vessels from any dysfunction. The oxidative damage that can happen to the heart is limited by Cardarine administration, and it does this by decreasing the build-up of plaque in the heart blood vessels. Besides, it can also reduce inflammation and lesions commonly associated with atherosclerosis. This is according to research conducted on mice which had anorexic heart arrhythmia.
Further studies have been conducted on obese guinea pigs. Administration of Cardarine showed a sudden reduction in the weight of the test subjects. The compound is known to promote fatty acid oxidation and blocking the supply of blood and nutrients to adipocytes. This is effective in reducing glucose to fat conversion and deposition of fats in the peripheral and visceral organs. Research showed that it increased insulin sensitivity, hence the level of glucose plasma reduced considerably. Cardarine also protects the kidneys from any kind of inflammation, and it ensures that the immune system of the test subject is top notch. Muscle growth and stamina are two other essential aspects of Cardarine. The compound aids in the generation of new muscle cells.
Potential Side Effects of Cardarine
Since Cardarine is not a steroid, studies have shown that administering the right dosage on the test subjects showed no side effects. The high specificity and affinity to target receptors means that it does not interact with receptors in different parts of the body, therefore not harming any other body parts. Further studies are still being conducted to determine the safe limits for the compound.