LGD-4033 (Ligandrol)

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Description

LGD 4033 is a non-steroidal selective androgen modular or SARM. Androgen is derived from a Greek word ‘andro’ which means male human being. The peptide is a synthetic compound that regulates the development and maintenance of male characteristics in vertebrates. It does this by binding to special receptors on the cells. A selective androgen receptor modulator is selective, and it targets specific tissues in the body. It has a high affinity for androgen, and it bonds with androgen receptors. When animals age or have autoimmune conditions, muscle mass and strength tends to reduce in a process called sarcopenia. Sarcopenia is known to increase the risk of fractures, falls and physical disability because of poor quality life and other effects.

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Ligandrol and Muscle Dystrophy
According to scientific research done on animal test subject chronic obstructive lung disease, end-stage renal disease, muscular dystrophy and lung cancer are some of the main contributors to the loss of physical function and muscle mass. Scientists are looking for ways to combat such problems by the use of Ligandrol and research is still underway on the animal test subjects. Anabolic therapies will help in dealing with the loss of muscle function. A common method of increasing muscle strength and mass is through the administration of testosterone. Selective androgen modulators are a class of androgen receptors that bind to specific tissues in the system.The SARMs targets anabolic pathways in a biological system.

In the past two decades, the main peptide that has been under research is Ligandrol. Ligandrol binds to androgen receptors with high affinity and selectivity. The peptide is known to produce positive effects on testosterone production. According to studies done on mice, LGD 4033 has shown to have desirable in vivo efficacy on bone density and skeletal muscles. The results published in scientific journals the peptide boosts the production of muscle and bone cells. An increase in myoblasts through differentiation, development, and maturity enhances muscle mass. Studies done on animal test subjects shows that the safety, pharmacokinetic and tolerability of the peptides is largely high on animal test subjects.

LGD 4033 Pharmacokinetics
A study done on guinea pigs randomized to placebo, 1.0 mg, 0.3 mg and 0.1 mg showed that those test subjects with 1.0 mg had the highest increased muscle mass, bone density, and high efficacy. Findings also proved that the peptide could be highly effective even in a low dosage of 0.1 mg. This can be exhibited by comparing the muscle mass of the test subject before and after study. The placebo registered no positive change in muscle mass and bone density.

Mechanism of Action
Ligandrol is a SARM and a novel non-steroidal oral peptide that has a high affinity and selectivity to the androgen receptors. This peptide was developed specifically to deal with muscle problems caused by acute diseases and age-related muscle loss.The mechanism of action is through the binding to androgen receptors. When it binds to the selective receptors, it has a high anabolic activity, and it boosts myoblasts and osteoclasts generation. According to the trials done on animal test subjects, Ligandrol showed a prolonged half-life of 24-36 hours. An enhanced half-life indicates that the peptide is highly effective in accentuating muscle and bone development. The manageable dosages of 0.1 mg to 1.0 mg showed no side effects on the test subjects. Studies revealed that there is a robust relationship between the blood plasma concentration and the dose administered.

Potential Benefits of Ligandrol
There are numerous benefits of Ligandrol based on the tests carried out on animal subjects. Some of the benefits include the following:

Increased weight and muscle tissue gain
Unlike prohormones and anabolic steroids, LGD 4033 is effective in boosting myoblastic differentiation, development, and maturity. This is essential in boosting muscle mass. On the other hand, bone cells are activated, and this helps in repair of dead or damaged cells.

Improved strength
According to research, the mice that were administered with the peptide showed increased activity and muscle activity. The studies show that muscle gain helped in giving the test subject increased strength.

Anti-catabolic
LGD 4033 is catabolic and it switches the body’s primary fuel source to body fat. This is largely effective in preventing muscle wasting.

Alleviates osteoporosis
The steroid is vital in improving the tendon and bones, therefore, alleviating osteoporosis. Studies reveal that the mice with osteoporosis improved considerably after the administration of the steroid.

Side Effects
Just like any other peptide in the market, Ligandrol has its side effects although research shows that there are minimal. It does not increase follicle stimulating hormone or luteinizing hormone. Fatigue, nausea, and vomiting can be some of the side effects on some of the test subjects. The peptide is sold in the market for research purposes only, and human consumption is not allowed. In summary, it is imperative that you take time in finding the supplier of the peptide. When you find a reliable peptide, you will be able to conduct a research a known accuracy and precision. Peptides are susceptible to changes in temperature, density, and other elements. Therefore, it should be stored in a freezer until when needed.