MK-677 or Nutrobal is a highly potent, orally active, long-acting non-peptide and selective agonist of growth hormone secretagogue and ghrelin receptor. The peptide works by mimicking the naturally produced growth hormone, and stimulates the production of ghrelin. Recent research indicated that MK 677 increased the level of insulin-like growth factor 1 and growth hormone. A secretagogue is a chemical which promotes the secretion of a hormone or prohormone. MK 677 induces the anterior lobe of the pituitary gland to produce growth hormone. Growth hormone is produced from the somatotrophs on the anterior lobe of the pituitary gland. Growth hormone plays an integral role in numerous biological processes such as blood sugar levels, metabolism, bone growth, weight, and composition. The hormone has metabolic functions, and it is very active in adolescents and children. However, as you age the production of growth hormone diminishes. This has several negative side effects that signify aging.
The effects of low growth hormone production include increased body fat, lower bone density, reduced energy and growth. Maintaining optimum levels of the growth hormone is effective in dealing with many side effects of ageing and certain illnesses. Currently, MK 677 is still under research for its potential benefits in accentuating wound healing, metabolism and promoting increase in muscle mass. According to research done on mice, exogenous growth hormone administration showed an improved capacity of build muscle mass, improved endurance, improved bone density and enhanced body composition. In most cases, the injection is done subcutaneously and the abdominal tissue gives an instant result when compared to other modes of administration.
What is the mechanism of action?
When MK 677 is injected into the test subject, the pituitary gland is activated, and the production of growth hormone is accentuated. The peptide is available in tincture, capsule or tablet and you can administer the dosage to the test subject depending on your preferred mode. When the peptide is administered, it has three benefits. These include reducing the level of somatostatin in a biological system, increasing the level of growth hormones and inhibiting the function of somatostatin. Somatostatin is a hormone that is produced in alternation with growth hormone at the pituitary gland. Therefore, when growth hormone production is high, somatostatin is low and vice versa. According to research done in 1998, scientists discovered that Nutrobal had therapeutic effects and they called it nonapeptide spiroperidine.
Findings from the research indicated that MK 677 promoted healthy nitrogen balance when it is combined with caloric reduction. The researchers also found out that the body retained more nitrogen than losing it. There are three important stages of nitrogen balance. Positive nitrogen balance is the ideal state of muscle, and it indicates that the muscles can recover quickly from high endurance sport or injury. Positive nitrogen intake with minimum output indicates that the muscles will recover quickly and easily and this state is called anabolic state. On the other hand, negative nitrogen balance is dangerous, and it involves more loss of nitrogen with less retention.
Characteristics of negative nitrogen balance include fatigue, muscle wasting, diminished recovery capacity, and immune system weakness. A body that is depleted of nitrogen makes cells repair a difficult process. Lastly, equilibrium is a state where the body consumes and dissipates the same amount of nitrogen. There are different ways of maximizing nitrogen balance, and one of the ways is through the administration of MK 677 and increasing amino acid intake.
Increased bone strength
According to research conducted on guinea pigs, the test subjects that had osteoporosis were treated in a controlled environment. The test subjects were scanned using X-ray to determine the bone density and their weights measured. After the administration of MK 677, most of the guinea pigs showed an increase in bone mineral density as well as overall weight. The test subjects that had hip fractures showed rapid healing. MK 677 promotes the secretion of growth hormone which stimulates the production of osteoblasts. This is important in promoting bone density, and it could be used in promoting bone density in elderly patients. However, it is important to note that the peptide is for research purposes only and human consumption is prohibited.
Muscle endurance is directly proportional to the strength of the muscle and ability to regain its strength after a strenuous exercise. MK 677 increases the generation of myoblasts or muscle cells and this is vital in boosting muscle repair and healing. Studies indicated that mice with the peptide showed aggressive and playful behavior unlike placebo.
Prevents tumor growth
According to studies done on mice, MK 677 was found to be highly effective in stopping tumor growth. Scientifically, mice and humans are related and the test subjects used in research means that the peptide could have nearly the same effect in humans. By creating more cells and promoting the production of growth hormone, the peptide is effective in promoting cell division, growth and development.
The dosage will vary from one test subject to another. However, the recommended dosage is 5 mg in the beginning, and you can move up to 12.5 mg once the test subject has built up some resistance or acclimatized to high dosage. It is important that you always monitor any adverse side effect such as blurred vision, redness, itching or swelling at the administration site.
Possible side effects of MK 677
Just like any other synthetic compound, MK 677 has potential side effects and this could range from increased facial hair in women, gynecomastia and small testes in men. Sleeping could be a problem because it alters normal brain function. Any method that is used to increase muscle size and nitrogen retention will affect REM sleep. However, it is important to note that these side effects are not severe. They are mild and can be mitigated by not injecting the peptide for a while.