YK-11 (Myostine)


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YK-11 is a synthetically manufactured selective androgen receptor modulator or SARM. The peptide is gene selective and partial agonist of the androgen receptor. However, it does not include physical interaction between LBD/AF2 and NTD/AF1, which is usually called N/C interaction that is required for complete tranasctivation of AR. The drug is anabolic in nature and has shown to have greater potency than dihydrotestosterone.

The myogenic differentiation of C2C12 myoblasts cells is induced by androgen receptor partial agonist and YK-11. Research shows that YK 11 is a SARM and activates AR without N/C interaction. In the study, the mechanism of action of the drug is through regulatory factors such as myogenin, myogenic factor 5 and myogenic differentiation factor.

Follistatin is expressed when YK 11 is administered to the test subject and the YK-11 mediated differentiation is reversed by anti-follistatin.

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Chemical Composition
The chemical structure is similar to that of steroids. It is a derivative of testosterone. However, it does not have steroidal properties. It is classified as a SARM and gives results similar to other androgen receptors.

YK-11 Mechanism of Action
YK-11 combines with androgen receptor and prompts the muscle cells to enhance its anabolic factors resulting in muscle growth. Unlike other SARMs, the compound is highly potent and accentuates the production of myoblasts at a higher rate than natural testosterone. The compound is synthesized to help muscle growth and it has been proven that it promotes muscle retention, muscle growth, and growth of new cells. The compound is ideal for test subjects to increase muscle mass because it keeps fat cells at bay. YK-11 is similar to testosterone in function. However, it was created to work on specific cells unlike testosterone which works on more cells in a biological system. When testosterone is administered for a long time, it will result in prostate growth and other severe side effects. Although SARMs are considered safer than steroids, it is imperative that you limit the dosage to the prescribed format. Increasing the dose rapidly will result in adverse side effects, such as liver conditions, among others. YK-11 was first discovered in the year 2011 by Yuichiro Kanno. He published results that confirmed that the peptide was really a SARM and that was more active than naturally produced hormones.

Anabolic Effects
There are many SARMs, which has limited androgenic effect. However, YK 11 is different because when it was administered to test subject, C2C12 cells increased rapidly. Exposing 500nmol to the cells and DHT showed that YK-11 is more potent and active in accentuating production of muscle cells. The SARM triggers the muscle cells to make more follistatin. YK -11 works with androgen receptors perfectly to induce the desired effects. The compound increases muscle strength by promoting burning of excess fat cells in the body and converting them into energy. It is recommended that you always start with low dosages before moving to higher dosages. This will make it easy for you to monitor any adverse side effect that may be caused by the compound.

YK-11 and Body Building
The compound is designed to increase muscle growth by accentuating myoblasts differentiation, development and maturity. It works in several ways to promote muscle endurance and mass. The compound promotes development of muscle cells and it helps muscle retention apart from burning excess fat on the peripheral and visceral organs. When the compound is introduced into the body, the tablets stimulates the production of muscle cells. It also increases strength of the muscles by increasing the number of mitochondria in the muscles. Dead mitochondria are excreted through normal detoxification process. YK-11 is more selective and you will be able to see results faster. It is designed to help test subjects that have poor genetic makeup which prevents muscle mass generation. It is imperative to note that YK-11 is a myostatin inhibitor. Myostatin is a protein that is known to inhibit muscle growth. Test subject with high levels of myostatin inhibitor, therefore they have little muscle mass.

YK-11 and DHT
YK-11 is more anabolic that any androgenic peptide, such as dihydrotestosterone and it has side effects. Some of the common side effects include prostate enlargement and this can be mitigated by taking low dosage as you move to higher dosages. YK-11 is effective and it comes with fewer side effects when compared to other compounds in its category. When the compound is administered to test subject, the compound accentuates effects as soon as possible. The half life of the SARM is 18 to 24 hours. For optimal functioning, it is important that you keep the test subjects busy throughout before you measure their muscle mass and energy retention.

The dosage or YK-11 varies depending on the objective of the research. You should begin with low dosage of 2 mg per day before moving to 5 mg and a maximum of 10 mg per day. The reaction of the test subject is effective and you should monitor it closely. In case of any severe side effects, you should discontinue the dose and repeat once the test subject is completely healed.

Potential Side Effects
YK-11 has a several mild side effects. One of the common side effect is hair growth. This can be a good thing or a bad thing depending on the test subject. Most notably is that YK-11 does not cause any androgenic effects, therefore, it does not contribute to prostate enlargement or development of female characteristics. There is no documentation of any side effect such as dependency of YK-11. It is imperative that you maintain dosage to avoid any complication that may arise during the research.

In summary, there is no doubt YK-11 is one of the most potent and active SARM. The compound shows a lot of promise and with little or mild side effects, more research needs to be done to understand it better. If you are looking for muscle mass solution, then you should research YK-11 by administering it to test subjects such as mice or guinea pigs and monitor their reactions.